Respiratory PCR detects influenza after intranasal live-attenuated influenza vaccination
نویسندگان
چکیده
منابع مشابه
Respiratory PCR detects influenza after intranasal live-attenuated influenza vaccination
From 2013 an annual nasal live-attenuated influenza vaccine (LAIV—Fluenz) is available for all children in the UK aged 2 and 3 years and other ‘at-risk’ children, as part of the National Health Service (NHS) childhood vaccination programme. 2 The vaccine contains reassortant influenza viruses; two influenza A viruses (H1N1 and H3N2) and one influenza B virus, and has previously been used in chi...
متن کاملImmune responses after live attenuated influenza vaccination
Since 2003 (US) and 2012 (Europe) the live attenuated influenza vaccine (LAIV) has been used as an alternative to the traditional inactivated influenza vaccines (IIV). The immune responses elicted by LAIV mimic natural infection and have been found to provide broader clinical protection in children compared to the IIVs. However, our knowledge of the detailed immunological mechanisims induced by...
متن کاملDuration of virus shedding after trivalent intranasal live attenuated influenza vaccination in adults.
OBJECTIVE To characterize the probability and duration of viral shedding among adults given trivalent live attenuated influenza vaccine (LAIV). DESIGN Prospective surveillance study. METHODS Nasal wash samples were collected from adult volunteers at baseline and on days 3, 7, and 10 and between days 17 and 21 following intranasal LAIV vaccination. The presence, titer, and identification of ...
متن کاملInfluenza Vaccination Strategies: Comparing Inactivated and Live Attenuated Influenza Vaccines
Influenza is a major respiratory pathogen causing annual outbreaks and occasional pandemics. Influenza vaccination is the major method of prophylaxis. Currently annual influenza vaccination is recommended for groups at high risk of complications from influenza infection such as pregnant women, young children, people with underlying disease and the elderly, along with occupational groups such a ...
متن کاملBoosted Influenza-Specific T Cell Responses after H5N1 Pandemic Live Attenuated Influenza Virus Vaccination
BACKGROUND In a phase I clinical trial, a H5N1 pandemic live attenuated influenza virus (pLAIV) VN2004 vaccine bearing avian influenza H5N1 hemagglutinin (HA) and NA genes on the A/Ann Arbor cold-adapted vaccine backbone displayed very restricted replication. We evaluated T cell responses to H5N1 pLAIV vaccination and assessed pre-existing T cell responses to determine whether they were associa...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 2013
ISSN: 0003-9888,1468-2044
DOI: 10.1136/archdischild-2013-305511